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Patents

Patents

If you are interested in exploring how Tioga Research might best help you advance your skin-applied product program, please contact us at info@tiogaresearch.com.
Minimally, we may be able to help you in your planning process.

 

Our capacity to undertake and complete client projects in an efficient manner derives in substantial part from the skills and experience of the Tioga Research team. It benefits also from the various technologies that we bring to bear, both conventional and proprietary.

 

Formulations technologies and screening patents:
Mitragotri S, Karande P: A Combinatorial Method for Rapid Screening of Drug Delivery Formulations. WO 02/16941 A2, 2001.

 

Newsam JM, Schunk SA, Klein J: Process for producing a multiplicity of building blocks of a library of materials. WO Patent WO 02/43860A2 (also German Patent DE 100 59 890 A1), 2002.

 

Newsam JM, Feygin I, King-Smith RD: Rapid Assaying of Formulations Applied to Fabric. US Provisional Patent Application, 2003.

 

Newsam JM, Feygin I, King-Smith RD, Jousse F, Jongen T: Screening of Microfluidic Processing Geometries.  US Provisional Patent Application, 2003.

 

Feygin I, Newsam JM: Fluid-handling systems and components comprising a bladder pump, and methods therefor. US Patent 6,733,252, 2004.

 

Feygin I, Newsam JM: Method and apparatus for quasi-continuous and quasi-simultaneous dispensing.  US Patent 6,742,549, 2004.

 

Strehlau W, Newsam JM, Demuth D, Stichert W, Brenner A, Schunk SA, Klein J: Computer-aided optimization of substance libraries. US Patent 6,862,533, 2005.

 

Feygin I, Newsam JM: Rotary-Drive Dispenser. US Patent 7,028,726, 2006.

 

Newsam JM, Feygin I, Mitragotri S, King-Smith RD: Apparatus and methods for evaluating the barrier properties of a membrane. US Patent 8,277,762, 2012.

 

Formulation compositions and methods of use patents:
Buyuktimkin S, Buyuktimkin N: Crystalline salts of dodecyl 2-(N, N-dimethylamino) propionate. US Patent 6,118,020, 2000.

 

Buyuktimkin S, Buyuktimkin N, Yeager JL: Topical compositions for NSAI drug delivery. US Patent 6,083,996, 2000.

 

Buyuktimkin S, Buyuktimkin N, Yeager JL: Topical compositions for prostaglandin E1 delivery. US Patent 6,046,244, 2000.

 

Yeager JL, Buyuktimkin N, Buyuktimkin S: Prostaglandin compositions and methods of treatment for male erectile dysfunction. US Patent 6,323,241, 2001.

 

Buyuktimkin S, Buyuktimkin N, Yeager JL: Topical compositions containing prostaglandin E1. US Patent 6,414,028, 2002.

 

Yeager JL, Buyuktimkin N, Buyuktimkin S: Compositions and methods for amelioration of human female sexual dysfunction. US Patent 6,486,207, 2002.

 

Kisak E, Coldren B, Kennedy M, Walker S, Zasadzinski J: Bilayer Structure Which Encapsulates Multiple Containment Units and Uses Thereof. US Patent 6,565,889, 2003.

 

Okada K, Yeager JL, Buyuktimkin N, Buyuktimkin S: Treatment of erectile dysfunction. US Patent Application 20030220292, 2003.

 

Yeager JL, Buyuktimkin N, Buyuktimkin S: Compositions and methods for amelioration of human female sexual dysfunction. US Patent 6,825,234, 2004.

 

Yeager JL, Buyuktimkin N, Buyuktimkin S: Prostaglandin compositions and methods of treatment for male erectile dysfunction. US Patent 6,693,135, 2004.

 

Yeager JL, Buyuktimkin N, Buyuktimkin S: Methods of treatment of male erectile dysfunction. US Patent Application 20040110843, 2004.

 

Buyuktimkin S, Buyuktimkin N, Yeager JL: Peroxide compounds for the prevention and treatment of sexual dysfunction in humans. US Patent Application 20050276865, 2005.

 

Buyuktimkin S, Buyuktimkin N, Yeager JL: Topical treatment and prevention of human papilloma virus (HPV) infection. US Patent Application 20050272700, 2005.

 

Buyuktimkin S, Buyuktimkin N, Yeager JL: Method for the long term stabilization of labile compounds at room temperature in pharmaceutical preparations containing water. US Patent Application 20050255161, 2005.

 

Buyuktimkin S, Buyuktimkin N, Yeager JL: Hydrocarbyl aminohydrocarbonoates and aminohydrocarbonol hydrocarbonoates as antimicrobial and antiviral agents. US Patent Application 20050113274, 2005.

 

Lu M, Mo JY, Yeager JL, Buyuktimkin N, Buyuktimkin S: Compositions and methods for amelioration of human female sexual dysfunction. US Patent Application 20050004226, 2005.

 

Yeager JL, Buyuktimkin N, Buyuktimkin S: Prostaglandin compositions and methods of treatment for male erectile dysfunction.  US Patent 7,105,571, 2006.

 

Kisak ET, King-Smith D, Galer BS, Newsam JM, Buyuktimkin N, Buyuktimkin S, Singh J: Formulations for the Treatment of Acute Herpes Zoster Pain.  PCT Patent Application PCT/US2009/063414 (Nov 5, 2009), 2009.

 

Kisak ET, Newsam JM, King-Smith D, Karande P, Mitragotri S: Topical formulation including diclofenac, or a pharmaceutically acceptable salt thereof.  US Patent 7,795,309, 2010.

 

Buyuktimkin N, Buyuktimkin S, Singh J, Newsam JM, King-Smith D, Kisak ET, Galer BS, Desai T, Riley C: Pharmaceutical Formulations and Methods of Use.  US Provisional Patent Application 61/237,252 (Aug 26, 2009) PCT Patent Application WO/2011/028629 (Mar 10, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Kisak E, Singh J, Newsam JM, King-Smith D, Galer BS: Foamable Formulation.  US Provisional Patent Application 61/312,629 (March 10, 2010) PCT Patent Application WO/2011/112875 (Sep 15, 2011) 2011.

 

Buyuktimkin S, Buyuktimkin N, Kisak ET, Singh J, Newsam JM, King-Smith D, Galer BS: Topical Etoricoxib Formulation.  US Provisional Patent Application 61/349,712 (May 28, 2010) PCT Patent Application WO/2011/ 149645  (December 1, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak E: Highly Permeating Terbinafine Formulation for Treating Onychomycosis.  US Provisional Patent Application 61/289,967 (Dec 23, 2009) PCT Patent Application WO/2011/079234 (Jun 30, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak E: Topical Eutectic-Based Formulations.  US Provisional Patent Application 61/230,473 (July 31, 2009) PCT Patent Application WO/2011/014850 (Feb 3, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak E, Galer BS: Topical Formulations.  US Provisional Patent Application 61/247,222 (Sept 30, 2009) PCT Patent Application WO/2011/041609 (Apr 7, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak ET, Galer BS: Topical Formulation Comprising Etoricoxib and a Zwitterionic Surfactant.  US Provisional Patent Application 61/250,452 (Oct 9, 2009) PCT Patent Application WO/2011/044540 (Apr 14, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak ET, Galer BS: Topical Etoricoxib Formulation Comprising an Eutectic Mixture of Permeation Enhancers.  US Provisional Patent Application 61/260,351 (Nov 11, 2009) PCT Patent Application WO/2011/060195 (May 19, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Kisak E, King-Smith D, Newsam JM, Singh J: Wound Dressings Comprising Chlorite.  PCT Patent Application WO 2012/106822 (Feb 9, 2012), 2012.

 

Buyuktimkin S, Buyuktimkin N, Kisak E, Newsam JM, King-Smith D, Singh J, Martin R: Foamable Compositions of Stabilized Chlorite.  PCT Patent Application WO/2012/019288 (Feb 16, 2012) 2012.

 

Kisak E, Singh J: Diclofenac topical formulation.  US 8,252,838 2012.

 

Singh J, Shainhouse JZ, Galer BS, King-Smith RD, Grierson LM, Burian M, Wilkin J, Kisak ET, Newsam JM: Treatment of pain with topical diclofenac.  US Patent 8,217,078, 2012.

 

Kisak E, Singh J: Diclofenac topical formulation.  US 8,563,613, 2013.

 

King-Smith D, Galer B, Newsam JM, Buyuktimkin N, Buyuktimkin S, Kisak ET, Singh J: Topical ibuprofen formulations.  US Patent 8,470,886, 2013.

 

Kisak ET, Newsam JM, King-Smith D, Karande P, Mitragotri S: Topical formulation.  US Patent 8,343,962, 2013.

 

Singh J, Shainhouse JZ, Galer BS, King-Smith RD, Grierson LM, Burian M, Wilkin J, Kisak ET, Newsam JM: Treatment of pain with topical diclofenac compounds.  US Patent 8,546,450, 2013.

 

Singh J, Shainhouse JZ, Galer BS, King-Smith RD, Grierson LM, Burian M, Wilkin J, Kisak ET, Newsam JM: Treatment of pain with topical diclofenac compounds.  US Patent 8,618,164, 2013.

 

Singh J, Shainhouse JZ, Galer BS, King-Smith RD, Grierson LM, Burian M, Wilkin J, Kisak ET, Newsam JM: Treatment of pain with topical diclofenac.  US Patent 8,741,956, 2014

Formulation compositions and methods of use patents:
Yeager JL, Buyuktimkin N, Buyuktimkin S: Prostaglandin compositions and methods of treatment for male erectile dysfunction. US Patent 7,105,571, 2006.

 

Kisak ET, King-Smith D, Galer BS, Newsam JM, Buyuktimkin N, Buyuktimkin S, Singh J: Formulations for the Treatment of Acute Herpes Zoster Pain. PCT Patent Application PCT/US2009/063414 (Nov 5, 2009), 2009.

 

Kisak ET, Newsam JM, King-Smith D, Karande P, Mitragotri S: Topical formulation including diclofenac, or a pharmaceutically acceptable salt thereof. US Patent 7,795,309, 2010.

 

Buyuktimkin N, Buyuktimkin S, Singh J, Newsam JM, King-Smith D, Kisak ET, Galer BS, Desai T, Riley C: Pharmaceutical Formulations and Methods of Use.  US Provisional Patent Application 61/237,252 (Aug 26, 2009) PCT Patent Application WO/2011/028629 (Mar 10, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Kisak E, Singh J, Newsam JM, King-Smith D, Galer BS: Foamable Formulation. US Provisional Patent Application 61/312,629 (March 10, 2010) PCT Patent Application WO/2011/112875 (Sep 15, 2011) 2011.

 

Buyuktimkin S, Buyuktimkin N, Kisak ET, Singh J, Newsam JM, King-Smith D, Galer BS: Topical Etoricoxib Formulation. US Provisional Patent Application 61/349,712 (May 28, 2010) PCT Patent Application WO/2011/ 149645  (December 1, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak E: Highly Permeating Terbinafine Formulation for Treating Onychomycosis. US Provisional Patent Application 61/289,967 (Dec 23, 2009) PCT Patent Application WO/2011/079234 (Jun 30, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak E: Topical Eutectic-Based Formulations.  US Provisional Patent Application 61/230,473 (July 31, 2009) PCT Patent Application WO/2011/014850 (Feb 3, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak E, Galer BS: Topical Formulations.  US Provisional Patent Application 61/247,222 (Sept 30, 2009) PCT Patent Application WO/2011/041609 (Apr 7, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak ET, Galer BS: Topical Formulation Comprising Etoricoxib and a Zwitterionic Surfactant.  US Provisional Patent Application 61/250,452 (Oct 9, 2009) PCT Patent Application WO/2011/044540 (Apr 14, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Singh J, Newsam JM, King-Smith D, Kisak ET, Galer BS: Topical Etoricoxib Formulation Comprising an Eutectic Mixture of Permeation Enhancers. US Provisional Patent Application 61/260,351 (Nov 11, 2009) PCT Patent Application WO/2011/060195 (May 19, 2011), 2011.

 

Buyuktimkin S, Buyuktimkin N, Kisak E, King-Smith D, Newsam JM, Singh J: Wound Dressings Comprising Chlorite. PCT Patent Application WO 2012/106822 (Feb 9, 2012), 2012.

 

Buyuktimkin S, Buyuktimkin N, Kisak E, Newsam JM, King-Smith D, Singh J, Martin R: Foamable Compositions of Stabilized Chlorite. PCT Patent Application WO/2012/019288 (Feb 16, 2012) 2012.

 

Kisak E, Singh J: Diclofenac topical formulation. US 8,252,838 2012.

 

Singh J, Shainhouse JZ, Galer BS, King-Smith RD, Grierson LM, Burian M, Wilkin J, Kisak ET, Newsam JM: Treatment of pain with topical diclofenac. US Patent 8,217,078, 2012.

 

Kisak E, Singh J: Diclofenac topical formulation. US 8,563,613, 2013.

 

King-Smith D, Galer B, Newsam JM, Buyuktimkin N, Buyuktimkin S, Kisak ET, Singh J: Topical ibuprofen formulations. US Patent 8,470,886, 2013.

 

Kisak ET, Newsam JM, King-Smith D, Karande P, Mitragotri S: Topical formulation. US Patent 8,343,962, 2013.

 

Singh J, Shainhouse JZ, Galer BS, King-Smith RD, Grierson LM, Burian M, Wilkin J, Kisak ET, Newsam JM: Treatment of pain with topical diclofenac compounds.  US Patent 8,546,450, 2013.

 

Singh J, Shainhouse JZ, Galer BS, King-Smith RD, Grierson LM, Burian M, Wilkin J, Kisak ET, Newsam JM: Treatment of pain with topical diclofenac compounds. US Patent 8,618,164, 2013.

 

Singh J, Shainhouse JZ, Galer BS, King-Smith RD, Grierson LM, Burian M, Wilkin J, Kisak ET, Newsam JM: Treatment of pain with topical diclofenac. US Patent 8,741,956, 2014